Context-Dependent Antagonism between Akt Inhibitors and Topoisomerase Poisons

Signaling through the phosphatidylinositol-3 kinase (PI3K)/Akt pathway, which is aberrantly activated in >50% of carcinomas, inhibits apoptosis and contributes to drug resistance. Accordingly, several Akt inhibitors are currently undergoing preclinical or early clinical testing. To examine the ef...

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Bibliographische Detailangaben
Hauptverfasser: Gálvez-Peralta, Marina, Flatten, Karen S., Loegering, David A., Peterson, Kevin L., Schneider, Paula A., Erlichman, Charles, Kaufmann, Scott H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990016/
https://ncbi.nlm.nih.gov/pubmed/24569089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.088674
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