Immunodetection of human topoisomerase I-DNA covalent complexes

A number of established and investigational anticancer drugs slow the religation step of DNA topoisomerase I (topo I). These agents induce cytotoxicity by stabilizing topo I-DNA covalent complexes, which in turn interact with advancing replication forks or transcription complexes to generate lethal...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Patel, Anand G., Flatten, Karen S., Peterson, Kevin L., Beito, Thomas G., Schneider, Paula A., Perkins, Angela L., Harki, Daniel A., Kaufmann, Scott H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824114/
https://ncbi.nlm.nih.gov/pubmed/26917015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw109
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