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Immunodetection of human topoisomerase I-DNA covalent complexes
A number of established and investigational anticancer drugs slow the religation step of DNA topoisomerase I (topo I). These agents induce cytotoxicity by stabilizing topo I-DNA covalent complexes, which in turn interact with advancing replication forks or transcription complexes to generate lethal...
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Publicado no: | Nucleic Acids Res |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824114/ https://ncbi.nlm.nih.gov/pubmed/26917015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw109 |
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