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Mitotic Phosphorylation Stimulates DNA Relaxation Activity of Human Topoisomerase I
Human DNA topoisomerase I (topo I) is an essential mammalian enzyme that regulates DNA supercoiling during transcription and replication. In addition, topo I is specifically targeted by the anticancer compound camptothecin and its derivatives. Previous studies have indicated that topo I is a phospho...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2423254/ https://ncbi.nlm.nih.gov/pubmed/18408216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802246200 |
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