PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells

The selective and temporal DNA methylation plays an important role in the self-renewal and differentiation of hematopoietic stem cells (HSCs), but the molecular mechanism that controls the dynamics of DNA methylation is not understood. Here, we report that the PIAS1 epigenetic pathway plays an impor...

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Bibliographic Details
Main Authors: Liu, Bin, Yee, Kathleen M, Tahk, Samuel, Mackie, Ryan, Hsu, Cary, Shuai, Ke
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989605/
https://ncbi.nlm.nih.gov/pubmed/24357619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201283326
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