PIAS1 Regulates Breast Tumorigenesis through Selective Epigenetic Gene Silencing

Epigenetic gene silencing by histone modifications and DNA methylation is essential for cancer development. The molecular mechanism that promotes selective epigenetic changes during tumorigenesis is not understood. We report here that the PIAS1 SUMO ligase is involved in the progression of breast tu...

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Detalhes bibliográficos
Main Authors: Liu, Bin, Tahk, Samuel, Yee, Kathleen M., Yang, Randy, Yang, Yonghui, Mackie, Ryan, Hsu, Cary, Chernishof, Vasili, O'Brien, Neil, Jin, Yusheng, Fan, Guoping, Lane, Timothy F., Rao, Jianyu, Slamon, Dennis, Shuai, Ke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933565/
https://ncbi.nlm.nih.gov/pubmed/24586797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089464
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