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The Ligase PIAS1 Restricts Natural Regulatory T Cell Differentiation by Epigenetic Repression
CD4(+)Foxp3(+) regulatory T (T(reg)) cells are important for maintaining immune tolerance. Understanding the molecular mechanism that regulates T(reg) differentiation will facilitate the development of effective therapeutic strategies against autoimmune diseases. We report here that the SUMO E3 liga...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3043201/ https://ncbi.nlm.nih.gov/pubmed/20966256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1193787 |
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