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The Ligase PIAS1 Restricts Natural Regulatory T Cell Differentiation by Epigenetic Repression

CD4(+)Foxp3(+) regulatory T (T(reg)) cells are important for maintaining immune tolerance. Understanding the molecular mechanism that regulates T(reg) differentiation will facilitate the development of effective therapeutic strategies against autoimmune diseases. We report here that the SUMO E3 liga...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Bin, Tahk, Samuel, Yee, Kathleen M., Fan, Guoping, Shuai, Ke
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043201/
https://ncbi.nlm.nih.gov/pubmed/20966256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1193787
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