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The Ligase PIAS1 Restricts Natural Regulatory T Cell Differentiation by Epigenetic Repression

CD4(+)Foxp3(+) regulatory T (T(reg)) cells are important for maintaining immune tolerance. Understanding the molecular mechanism that regulates T(reg) differentiation will facilitate the development of effective therapeutic strategies against autoimmune diseases. We report here that the SUMO E3 liga...

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Hlavní autoři: Liu, Bin, Tahk, Samuel, Yee, Kathleen M., Fan, Guoping, Shuai, Ke
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043201/
https://ncbi.nlm.nih.gov/pubmed/20966256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1193787
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