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Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics
We examined whether age alters the emergence of high-affinity germinal center B (GCB) cells and switched memory B cells (swB(mem)) during a primary immune response to a thymus-dependent antigen, using a novel flow cytometric assay to distinguish relative BCR affinity. In young mice, high-affinity B...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989373/ https://ncbi.nlm.nih.gov/pubmed/24389058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2013.12.013 |
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