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Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics

We examined whether age alters the emergence of high-affinity germinal center B (GCB) cells and switched memory B cells (swB(mem)) during a primary immune response to a thymus-dependent antigen, using a novel flow cytometric assay to distinguish relative BCR affinity. In young mice, high-affinity B...

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Detalhes bibliográficos
Main Authors: Goenka, Radhika, Scholz, Jean L., Naradikian, Martin S., Cancro, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989373/
https://ncbi.nlm.nih.gov/pubmed/24389058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2013.12.013
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