Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-x (L) Transgenic Mice

The role of apoptosis in affinity maturation was investigated by determining the affinity of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and serum antibody in transgenic mice that overexpress a suppressor of apoptosis, Bcl-x(L), in the B cell compartment. Although tra...

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Main Authors: Takahashi, Yoshimasa, Cerasoli, Douglas M., Dal Porto, Joseph M., Shimoda, Michiko, Freund, Robert, Fang, Wei, Telander, David G., Malvey, Erika-Nell, Mueller, Daniel L., Behrens, Timothy W., Kelsoe, Garnett
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195593/
https://ncbi.nlm.nih.gov/pubmed/10430628
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