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Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism

Previous studies have shown that whole body deletion of the glucagon receptor suppresses the ability of starvation to increase hepatic fibroblast growth factor 21 (FGF21) expression and plasma FGF21 concentration. Here, we investigate the mechanism by which glucagon receptor activation increases hep...

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Autori principali: Cyphert, Holly A., Alonge, Kimberly M., Ippagunta, Siri M., Hillgartner, F. Bradley
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986400/
https://ncbi.nlm.nih.gov/pubmed/24733293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094996
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