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Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism

Previous studies have shown that whole body deletion of the glucagon receptor suppresses the ability of starvation to increase hepatic fibroblast growth factor 21 (FGF21) expression and plasma FGF21 concentration. Here, we investigate the mechanism by which glucagon receptor activation increases hep...

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Detalhes bibliográficos
Main Authors: Cyphert, Holly A., Alonge, Kimberly M., Ippagunta, Siri M., Hillgartner, F. Bradley
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986400/
https://ncbi.nlm.nih.gov/pubmed/24733293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094996
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