A Chemical Genetics Analysis of the Roles of Bypass Polymerase DinB and DNA Repair Protein AlkB in Processing N (2)-Alkylguanine Lesions In Vivo

DinB, the E. coli translesion synthesis polymerase, has been shown to bypass several N (2)-alkylguanine adducts in vitro, including N (2)-furfurylguanine, the structural analog of the DNA adduct formed by the antibacterial agent nitrofurazone. Recently, it was demonstrated that the Fe(II)- and α-ket...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Shrivastav, Nidhi, Fedeles, Bogdan I., Li, Deyu, Delaney, James C., Frick, Lauren E., Foti, James J., Walker, Graham C., Essigmann, John M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2014
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986394/
https://ncbi.nlm.nih.gov/pubmed/24733044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094716
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