Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium

Accumulation of lipofuscin bisretinoids (LBs) in the retinal pigment epithelium (RPE) is the alleged cause of retinal degeneration in genetic blinding diseases (e.g., Stargardt) and a possible etiological agent for age-related macular degeneration. Currently, there are no approved treatments for the...

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Autores principales: Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986126/
https://ncbi.nlm.nih.gov/pubmed/24706818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400530111
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