Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium

Accumulation of lipofuscin bisretinoids (LBs) in the retinal pigment epithelium (RPE) is the alleged cause of retinal degeneration in genetic blinding diseases (e.g., Stargardt) and a possible etiological agent for age-related macular degeneration. Currently, there are no approved treatments for the...

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Detalhes bibliográficos
Main Authors: Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986126/
https://ncbi.nlm.nih.gov/pubmed/24706818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400530111
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