Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium

Accumulation of lipofuscin bisretinoids (LBs) in the retinal pigment epithelium (RPE) is the alleged cause of retinal degeneration in genetic blinding diseases (e.g., Stargardt) and a possible etiological agent for age-related macular degeneration. Currently, there are no approved treatments for the...

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Main Authors: Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986126/
https://ncbi.nlm.nih.gov/pubmed/24706818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400530111
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