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Side Chain Conformational Averaging in Human Dihydrofolate Reductase
[Image: see text] The three-dimensional structures of the dihydrofolate reductase enzymes from Escherichia coli (ecDHFR or ecE) and Homo sapiens (hDHFR or hE) are very similar, despite a rather low level of sequence identity. Whereas the active site loops of ecDHFR undergo major conformational rearr...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985697/ https://ncbi.nlm.nih.gov/pubmed/24498949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4015314 |
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