Side Chain Conformational Averaging in Human Dihydrofolate Reductase

[Image: see text] The three-dimensional structures of the dihydrofolate reductase enzymes from Escherichia coli (ecDHFR or ecE) and Homo sapiens (hDHFR or hE) are very similar, despite a rather low level of sequence identity. Whereas the active site loops of ecDHFR undergo major conformational rearr...

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Bibliographic Details
Main Authors: Tuttle, Lisa M., Dyson, H. Jane, Wright, Peter E.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985697/
https://ncbi.nlm.nih.gov/pubmed/24498949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4015314
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