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Concise Enantiospecific Total Synthesis of Tubingensin A

[Image: see text] We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds.

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Bibliographische Detailangaben
Hauptverfasser: Goetz, Adam E., Silberstein, Amanda L., Corsello, Michael A., Garg, Neil K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985696/
https://ncbi.nlm.nih.gov/pubmed/24524351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501142e
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