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A Concise Total Synthesis of (±)-Vibralactone

Disclosed is a five-step synthesis of (±)-vibralactone, a biologically active terpenoid natural product. A key photochemical valence isomerization of 3-prenyl-pyran-2-one forges both the all-carbon quaternary stereocenter and the β-lactone at an early stage. Cyclopropanation of the resulting bicycli...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Nistanaki, Sepand K., Boralsky, Luke A., Pan, Roy D., Nelson, Hosea M.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351154/
https://ncbi.nlm.nih.gov/pubmed/30548983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201812711
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