PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

Poly(ADP-ribose) polymerases (PARP) attach poly(ADP-ribose) (PAR) chains to various proteins including themselves and chromatin. Topoisomerase I (Top1) regulates DNA supercoiling and is the target of camptothecin and indenoisoquinoline anticancer drugs, as it forms Top1 cleavage complexes (Top1cc) t...

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Dettagli Bibliografici
Autori principali: Das, Benu Brata, Huang, Shar-yin N., Murai, Junko, Rehman, Ishita, Amé, Jean-Christophe, Sengupta, Souvik, Das, Subhendu K., Majumdar, Papiya, Zhang, Hongliang, Biard, Denis, Majumder, Hemanta K., Schreiber, Valérie, Pommier, Yves
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985661/
https://ncbi.nlm.nih.gov/pubmed/24493735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku088
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