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Design and Synthesis of Heterocyclic Cations for Specific DNA Recognition: From AT-Rich to Mixed-Base-Pair DNA Sequences

[Image: see text] The compounds synthesized in this research were designed with the goal of establishing a new paradigm for mixed-base-pair DNA sequence-specific recognition. The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base pair sites in the DNA minor groove....

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Main Authors: Chai, Yun, Paul, Ananya, Rettig, Michael, Wilson, W. David, Boykin, David W.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985508/
https://ncbi.nlm.nih.gov/pubmed/24422528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo402599s
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