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Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication

Wip1 (protein phosphatase Mg(2+)/Mn(2+)-dependent 1D, Ppm1d) is a nuclear serine/threonine protein phosphatase that is induced by p53 following the activation of DNA damage response (DDR) signaling. Ppm1d(−/−) mouse embryonic fibroblasts (MEFs) exhibit premature senescence under conventional culture...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sakai, Hiroyasu, Fujigaki, Hidetsugu, Mazur, Sharlyn J, Appella, Ettore
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984300/
https://ncbi.nlm.nih.gov/pubmed/24552809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27920
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