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Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-x(L) ratio
Wip1 is a stress-response phosphatase that negatively regulates several tumor suppressors, including p53. In a sizeable fraction of tumors, overexpression or amplification of Wip1 compromises p53 functions; inhibition of Wip1 activity is an attractive strategy for improving treatment of these tumors...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359118/ https://ncbi.nlm.nih.gov/pubmed/22544321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.19901 |
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