Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

PPM1D (Wip1), a type PP2C phosphatase, is expressed at low levels in most normal tissues but is overexpressed in several types of cancers. In cells containing wild-type p53, the levels of PPM1D mRNA and protein increase following exposure to genotoxic stress, but the mechanism of regulation by p53 w...

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Main Authors: Rossi, Matteo, Demidov, Oleg N., Anderson, Carl W., Appella, Ettore, Mazur, Sharlyn J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2008
נושאים:
Molecular Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602757/
https://ncbi.nlm.nih.gov/pubmed/19015127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn888
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