2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease

Recently, we described the aminothiazole lead (4-biphenyl-4-yl-thiazol-2-yl)-(6-methyl-pyridin-2-yl)-amine (1), which exhibits many desirable properties, including excellent stability in liver microsomes, oral bioavailability of ∼40% and high exposure in the brains of mice. Despite its good pharmaco...

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Bibliographische Detailangaben
Hauptverfasser: Li, Zhe, Silber, B. Michael, Rao, Satish, Gever, Joel, Bryant, Clifford, Gallardo-Godoy, Alejandra, Dolghih, Elena, Widjaja, Kartika, Elepano, Manuel, Jacobson, Matthew P., Prusiner, Stanley B., Renslo, Adam R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984044/
https://ncbi.nlm.nih.gov/pubmed/23509039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300007
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