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2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease
Recently, we described the aminothiazole lead (4-biphenyl-4-yl-thiazol-2-yl)-(6-methyl-pyridin-2-yl)-amine (1), which exhibits many desirable properties, including excellent stability in liver microsomes, oral bioavailability of ∼40% and high exposure in the brains of mice. Despite its good pharmaco...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984044/ https://ncbi.nlm.nih.gov/pubmed/23509039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300007 |
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