Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells

PURPOSE: Previous studies showed that lowering PrP(C) concomitantly reduced PrP(Sc) in the brains of mice inoculated with prions. We aimed to develop assays that measure PrP(C) on the surface of human T98G glioblastoma and IMR32 neuroblastoma cells. Using these assays, we sought to identify chemical...

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Bibliografiske detaljer
Main Authors: Silber, B. Michael, Gever, Joel R., Rao, Satish, Li, Zhe, Renslo, Adam R., Widjaja, Kartika, Wong, Casper, Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Irwin, John J., Jacobson, Matthew P., Prusiner, Stanley B.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984052/
https://ncbi.nlm.nih.gov/pubmed/24530226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.01.001
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