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Dephosphorylation of γH2AX by WIP1: An important homeostatic regulatory event in DNA repair and cell cycle control

DNA double strand breaks are a particularly toxic form of DNA damage and the mammalian cell has evolved an intricate set of responses to repair this type of DNA lesion. A key early event in the DNA damage response (DDR) is ATM phosphorylation of the histone variant H2AX at serine 139 at the site of...

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Main Authors: Moon, Sung-Hwan, Nguyen, Thuy-Ai, Darlington, Yolanda, Lu, Xiongbin, Donehower, Lawrence A.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984036/
https://ncbi.nlm.nih.gov/pubmed/20495376
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