4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth

[Image: see text] 4′-Phosphopantetheinyl transferases (PPTases) catalyze a post-translational modification essential to bacterial cell viability and virulence. We present the discovery and medicinal chemistry optimization of 2-pyridinyl-N-(4-aryl)piperazine-1-carbothioamides, which exhibit submicrom...

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Detalhes bibliográficos
Main Authors: Foley, Timothy L., Rai, Ganesha, Yasgar, Adam, Daniel, Thomas, Baker, Heather L., Attene-Ramos, Matias, Kosa, Nicolas M., Leister, William, Burkart, Michael D., Jadhav, Ajit, Simeonov, Anton, Maloney, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983359/
https://ncbi.nlm.nih.gov/pubmed/24450337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401752p
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