Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

The helical cytokine interleukin (IL) 6 and its specific binding subunit IL-6R alpha form a 1:1 complex which, by promoting homodimerization of the signalling subunit gp130 on the surface of target cells, triggers intracellular responses. We expressed differently tagged forms of gp130 and used them...

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Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Paonessa, G, Graziani, R, De Serio, A, Savino, R, Ciapponi, L, Lahm, A, Salvati, A L, Toniatti, C, Ciliberto, G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398293/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7744001/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07186.x
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