Rational design of a receptor super-antagonist of human interleukin-6.

Por Savino, R, Ciapponi, L, Lahm, A, Demartis, A, Cabibbo, A, Toniatti, C, Delmastro, P, Altamura, S, Ciliberto, G
Publicado em 1994

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Por Savino, R, Lahm, A, Salvati, A L, Ciapponi, L, Sporeno, E, Altamura, S, Paonessa, G, Toniatti, C, Ciliberto, G
Publicado em 1994

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Por Paonessa, G, Graziani, R, De Serio, A, Savino, R, Ciapponi, L, Lahm, A, Salvati, A L, Toniatti, C, Ciliberto, G
Publicado em 1995

High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to...

Por PIGNATTI, P, CIAPPONI, L, GALLE, P, HANSEN, M B, MASSA, M, MEAZZA, C, PAONESSA, G, NOVICK, D, CILIBERTO, G, MARTINI, A, DE BENEDETTI, F
Publicado em 2003