Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Interleukin-6 (IL-6) drives the sequential assembly of a receptor complex formed by the IL-6 receptor (IL-6R alpha) and the signal transducing subunit, gp130. A model of human IL-6 (hIL-6) was constructed by homology using the structure of bovine granulocyte colony stimulating factor. The modeled cy...

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Vydáno v:EMBO J
Hlavní autoři: Savino, R, Lahm, A, Salvati, A L, Ciapponi, L, Sporeno, E, Altamura, S, Paonessa, G, Toniatti, C, Ciliberto, G
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394953/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7511100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06389.x
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