Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.

Interleukin-6 (IL-6) triggers the formation of a high affinity receptor complex with the ligand binding subunit IL-6Ralpha and the signal transducing chain gp130. Since the intracytoplasmic region of the IL-6Ralpha does not contribute to signaling, soluble forms of the extracytoplasmic domain (sIL-6...

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Bibliografische gegevens
Gepubliceerd in:EMBO J
Hoofdauteurs: Toniatti, C, Cabibbo, A, Sporena, E, Salvati, A L, Cerretani, M, Serafini, S, Lahm, A, Cortese, R, Ciliberto, G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 1996
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Research Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450208/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8654370/
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