Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

The helical cytokine interleukin (IL) 6 and its specific binding subunit IL-6R alpha form a 1:1 complex which, by promoting homodimerization of the signalling subunit gp130 on the surface of target cells, triggers intracellular responses. We expressed differently tagged forms of gp130 and used them...

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Detaylı Bibliyografya
Asıl Yazarlar: Paonessa, G, Graziani, R, De Serio, A, Savino, R, Ciapponi, L, Lahm, A, Salvati, A L, Toniatti, C, Ciliberto, G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1995
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC398293/
https://ncbi.nlm.nih.gov/pubmed/7744001
Etiketler: Etiketle
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