Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

One of the factors affecting the pharmacokinetics (PK) of a drug during pregnancy is the activity of hepatic and placental metabolizing enzymes. Recently, we reported on the biotransformation of glyburide by human hepatic and placental microsomes to six metabolites that are structurally identical be...

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Main Authors: Zharikova, Olga L., Fokina, Valentina M., Nanovskaya, Tatiana N., Hill, Ronald A., Mattison, Donald R., Hankins, Gary D.V., Ahmed, Mahmoud S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982398/
https://ncbi.nlm.nih.gov/pubmed/19679108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.08.003
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