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Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons

Recent data from our laboratory revealed the formation of an unknown metabolite of 17 hydroxyprogestrone caproate (17-HPC), used for treatment of preterm deliveries, during its perfusion across the dually perfused human placental lobule. Previously, we demonstrated that the drug is not hydrolyzed, n...

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Hlavní autoři: Yan, Ru, Nanovskaya, Tatiana N., Zharikova, Olga L., Mattison, Donald R., Hankins, Gary D.V., Ahmed, Mahmoud S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408387/
https://ncbi.nlm.nih.gov/pubmed/18329004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.013
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