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Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart

Excitation-contraction coupling (ECC) in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca(2+) transport. Voltage- and Ca(2+)-dependent L-type Ca(2+) channels (LCCs) allow for Ca(2+) entry into the myocyte, which then binds to nearby ryanodine receptors...

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Autors principals: Greenstein, Joseph L., Foteinou, Panagiota T., Hashambhoy-Ramsay, Yasmin L., Winslow, Raimond L.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982069/
https://ncbi.nlm.nih.gov/pubmed/24772082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00060
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