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CaMKII-dependent Activation of Late I(Na) Contributes to Cellular Arrhythmia in a Model of the Cardiac Myocyte

Cardiac voltage-gated Na(+) channels underlie membrane depolarization during the upstroke of the action potential (AP). These channels also exhibit a late, slowly-inactivating component of current (late I(Na)) that may be enhanced under pathological conditions such as heart failure, and may therefor...

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Autors principals: Hashambhoy, Yasmin L., Winslow, Raimond L., Greenstein, Joseph L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517881/
https://ncbi.nlm.nih.gov/pubmed/22255378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/IEMBS.2011.6091155
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