Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.

Compound A723U, a 2-acetylpyridine thiosemicarbazone, produced apparent inactivation of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. Inactivation occurred after A723U formed a reversible complex with the enzyme and only while the enzyme was catalyzing the formation of deoxynucleotid...

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Bibliografiske detaljer
Main Authors: Spector, T, Averett, D R, Nelson, D J, Lambe, C U, Morrison, R W, St Clair, M H, Furman, P A
Format: Artigo
Sprog:Inglês
Udgivet: 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC397975/
https://ncbi.nlm.nih.gov/pubmed/2987969
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