Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.

Compound A723U, a 2-acetylpyridine thiosemicarbazone, produced apparent inactivation of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. Inactivation occurred after A723U formed a reversible complex with the enzyme and only while the enzyme was catalyzing the formation of deoxynucleotid...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Spector, T, Averett, D R, Nelson, D J, Lambe, C U, Morrison, R W, St Clair, M H, Furman, P A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2987969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.12.4254
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