Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.

Compound A723U, a 2-acetylpyridine thiosemicarbazone, produced apparent inactivation of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. Inactivation occurred after A723U formed a reversible complex with the enzyme and only while the enzyme was catalyzing the formation of deoxynucleotid...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Spector, T, Averett, D R, Nelson, D J, Lambe, C U, Morrison, R W, St Clair, M H, Furman, P A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1985
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397975/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2987969/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.12.4254
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