Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.
Compound A723U, a 2-acetylpyridine thiosemicarbazone, produced apparent inactivation of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. Inactivation occurred after A723U formed a reversible complex with the enzyme and only while the enzyme was catalyzing the formation of deoxynucleotid...
Spremljeno u:
| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1985
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2987969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.12.4254 |
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