The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity

Accurate DNA synthesis in vivo depends on the ability of DNA polymerases to select dNTPs from a nucleotide pool dominated by NTPs. High fidelity replicative polymerases have evolved to efficiently exclude NTPs while copying long stretches of undamaged DNA. However, to bypass DNA damage, cells utiliz...

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Bibliographische Detailangaben
Hauptverfasser: Donigan, Katherine A., McLenigan, Mary P., Yang, Wei, Goodman, Myron F., Woodgate, Roger
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979402/
https://ncbi.nlm.nih.gov/pubmed/24532793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545442
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