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No Impact of Lentiviral Transduction on Hematopoietic Stem/Progenitor Cell Telomere Length or Gene Expression in the Rhesus Macaque Model

The occurrence of clonal perturbations and leukemia in patients transplanted with gamma-retroviral (RV) vector–transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions may perturb adjacent proto-oncogene expr...

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Autores principales: Sellers, Stephanie E, Dumitriu, Bogdan, Morgan, Mary J, Hughes, William M., Wu, Colin O, Raghavarchari, Nalini, Yang, Yanqin, Uchida, Naoya, Tisdale, John F, An, Dong S, Chen, Irvin S, Hematti, Peiman, Donahue, Robert E, LaRochelle, Andre, Young, Neal S, Calado, Rodrigo T, Dunbar, Cynthia E
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978805/
https://ncbi.nlm.nih.gov/pubmed/23863881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.168
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