Immunotherapy-induced CD8(+) T Cells Instigate Immune Suppression in the Tumor

Despite clear evidence of immunogenicity, cancer vaccines only provide a modest clinical benefit. To evaluate the mechanisms that limit tumor regression following vaccination, we have investigated the weak efficacy of a highly immunogenic experimental vaccine using a murine melanoma model. We discov...

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Detalhes bibliográficos
Main Authors: McGray, A J Robert, Hallett, Robin, Bernard, Dannie, Swift, Stephanie L, Zhu, Ziqiang, Teoderascu, Florentina, VanSeggelen, Heather, Hassell, John A, Hurwitz, Arthur A, Wan, Yonghong, Bramson, Jonathan L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978796/
https://ncbi.nlm.nih.gov/pubmed/24196579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.255
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