Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients

We have developed a recombinant adenovirus vaccine encoding dopachrome tautomerase (rHuAd5-hDCT) that produces robust DCT-specific immunity, but only provides modest suppression of murine melanoma. In the current study, an agonist antibody against 4-1BB was shown to enhance rHuAd5-hDCT efficacy and...

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Detalhes bibliográficos
Main Authors: McGray, A.J. Robert, Bernard, Dannie, Hallett, Robin, Kelly, Ryan, Jha, Mayank, Gregory, Caitlin, Bassett, Jennifer D., Hassell, John A., Pare, Guillaume, Wan, Yonghong, Bramson, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382903/
https://ncbi.nlm.nih.gov/pubmed/22754760
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