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Multi-constraint Computational Design Suggests that Native Sequences of Germline Antibody H3 Loops are Nearly Optimal for Conformational Flexibility
The limited size of the germline antibody repertoire has to recognize a far larger number of potential antigens. The ability of a single antibody to bind multiple ligands due to conformational flexibility in the antigen-binding site can significantly enlarge the repertoire. Among the six hyper-varia...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3978785/ https://ncbi.nlm.nih.gov/pubmed/19194863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22293 |
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