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Assessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin–HER2 interface

Computational protein design methods can complement experimental screening and selection techniques by predicting libraries of low-energy sequences compatible with a desired structure and function. Incorporating backbone flexibility in computational design allows conformational adjustments that shou...

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Autors principals: Babor, Mariana, Mandell, Daniel J, Kortemme, Tanja
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104238/
https://ncbi.nlm.nih.gov/pubmed/21465611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.632
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