Phase II Trial of Erlotinib during and after Radiotherapy in Children with Newly Diagnosed High-Grade Gliomas

Background: Epidermal growth factor receptor is overexpressed in most pediatric high-grade gliomas (HGG). Since erlotinib had shown activity in adults with HGG, we conducted a phase II trial of erlotinib and local radiotherapy (RT) in children with newly diagnosed HGG. Methods: Following maximum sur...

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Hlavní autoři: Qaddoumi, Ibrahim, Kocak, Mehmet, Pai Panandiker, Atmaram S., Armstrong, Gregory T., Wetmore, Cynthia, Crawford, John R., Lin, Tong, Boyett, James M., Kun, Larry E., Boop, Fredrick A., Merchant, Thomas E., Ellison, David W., Gajjar, Amar, Broniscer, Alberto
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978340/
https://ncbi.nlm.nih.gov/pubmed/24744992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00067
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