Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

PURPOSE: Testing of promising drug combinations is crucial in the treatment of diffuse intrinsic pontine glioma (DIPG). Since the VEGF and PDGF pathways are critical in gliomas, we evaluated the safety, maximum tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of vandetanib, a VEGFR-2 inh...

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Bibliografski detalji
Glavni autori: Broniscer, Alberto, Baker, Sharyn D., Wetmore, Cynthia, Pai Panandiker, Atmaram S., Huang, Jie, Davidoff, Andrew M., Onar-Thomas, Arzu, Panetta, John C., Chin, Thomas K., Merchant, Thomas E., Baker, Justin N., Kaste, Sue C., Gajjar, Amar, Stewart, Clinton F.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685168/
https://ncbi.nlm.nih.gov/pubmed/23536435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0306
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