Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma

BACKGROUND: Progressive/recurrent high-grade and diffuse intrinsic pontine gliomas (DIPGs) are fatal. Treatments targeting molecular pathways critical for these cancers are needed. METHODS: We conducted a phase 1 study (rolling-6 design) to establish the safety and maximum tolerated dose (MTD) of da...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Broniscer, Alberto, Jia, Sujuan, Mandrell, Belinda, Hamideh, Dima, Huang, Jie, Onar-Thomas, Arzu, Gajjar, Amar, Raimondi, Susana C., Tatevossian, Ruth G., Stewart, Clinton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980705/
https://ncbi.nlm.nih.gov/pubmed/29512900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.27035
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados