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Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma
BACKGROUND: Progressive/recurrent high-grade and diffuse intrinsic pontine gliomas (DIPGs) are fatal. Treatments targeting molecular pathways critical for these cancers are needed. METHODS: We conducted a phase 1 study (rolling-6 design) to establish the safety and maximum tolerated dose (MTD) of da...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Pediatr Blood Cancer |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980705/ https://ncbi.nlm.nih.gov/pubmed/29512900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.27035 |
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