Phase I Study of Vandetanib During and After Radiotherapy in Children With Diffuse Intrinsic Pontine Glioma

PURPOSE: To evaluate the safety, maximum-tolerated dose, pharmacokinetics, and pharmacodynamics of vandetanib, an oral vascular endothelial growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor inhibitor, administered once daily during and after radiotherapy in children with newly d...

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Detalhes bibliográficos
Main Authors: Broniscer, Alberto, Baker, Justin N., Tagen, Michael, Onar-Thomas, Arzu, Gilbertson, Richard J., Davidoff, Andrew M., Panandiker, Atmaram Pai, Leung, Wing, Chin, Thomas K., Stewart, Clinton F., Kocak, Mehmet, Rowland, Christopher, Merchant, Thomas E., Kaste, Sue C., Gajjar, Amar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020706/
https://ncbi.nlm.nih.gov/pubmed/20921456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.30.3545
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